Near-infrared light at 808nm reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons in Alzheimer's disease in vitro model

Iuliia Golovynska; Yurii V. Stepanov; Renlong Zhang; Sergii Golovynskyi; Liudmyla V. Garmanchuk; Tymish Y. Ohulchanskyy; Junle Qu

doi:10.1117/12.3002276

13 March 2024 Near-infrared light at 808nm reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons in Alzheimer's disease in vitro model

Iuliia Golovynska, Yurii V. Stepanov, Renlong Zhang, Sergii Golovynskyi, Liudmyla V. Garmanchuk, Tymish Y. Ohulchanskyy, Junle Qu

Author Affiliations +

Proceedings Volume PC12826, Mechanisms of Photobiomodulation Therapy XVIII; PC128260E (2024) https://doi.org/10.1117/12.3002276
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Photobiomodulation (PBM) of both oxidative stress and microglia metabolism associated with the activation of metabolic processes by 808 nm near-infrared light is carried out on microglia cells treated with β-amyloid. The light induces a metabolic shift from glycolysis to mitochondrial activity in pro-inflammatory microglia affected by Aβ. Thereby, the level of anti-inflammatory microglia increases. This process is accompanied by a decrease in pro-inflammatory cytokines and an activation of phagocytosis. Light exposure decreases the Aβ-induced activity of glucose-6-phosphate dehydrogenase, an enzyme that regulates the rate of the pentose phosphate pathway, which activates nicotinamide adenine dinucleotide phosphate oxidases to further produce ROS. During co-cultivation of neurons with microglia, light prevents the death of neurons, which is caused by ROS produced by Aβ-altered microglia. These original data clarify reasons for how PBM protects against neurodegeneration and support the use of light for therapeutic research in the treatment of Alzheimer's disease.

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Iuliia Golovynska, Yurii V. Stepanov, Renlong Zhang, Sergii Golovynskyi, Liudmyla V. Garmanchuk, Tymish Y. Ohulchanskyy, and Junle Qu "Near-infrared light at 808nm reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons in Alzheimer's disease in vitro model", Proc. SPIE PC12826, Mechanisms of Photobiomodulation Therapy XVIII, PC128260E (13 March 2024); https://doi.org/10.1117/12.3002276

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