Hypertension provokes the development of cerebral microhemorrhages and vascular injury in a mouse model

Danny F. Xie; Christian Crouzet; Chuo Fang; Han Liu; Jihua Liu; Donghy Lee; Adrian Vallejo; Annlia Paganini-Hill; Wei Ling Lau; David Cribbs; Mark Fisher; Bernard Choi

doi:10.1117/12.3002206

13 March 2024 Hypertension provokes the development of cerebral microhemorrhages and vascular injury in a mouse model

Danny F. Xie, Christian Crouzet, Chuo Fang, Han Liu, Jihua Liu, Donghy Lee, Adrian Vallejo, Annlia Paganini-Hill, Wei Ling Lau, David Cribbs, Mark Fisher, Bernard Choi

Author Affiliations +

Proceedings Volume PC12828, Neural Imaging and Sensing 2024; PC128280J (2024) https://doi.org/10.1117/12.3002206
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

The cerebral vasculature facilitates blood flow to maintain normal function in the brain. Vascular injury can impair the ability of the cerebral vasculature to regulate blood flow and preserve the integrity of the blood-brain barrier. Cerebral microhemorrhages (CMH) are an indicator of structural damage in the brain vasculature. Aging and hypertension are the most common risk factors for CMH. In this study, we analyzed the effect of hypertension on resting-state cerebral blood flow and the development of CMH in a mouse model of aging. A reduction in resting-state cerebral blood flow was observed in hypertension mice. CMH were found to appear nearest to capillary-sized vessels. Together, these findings demonstrate hypertension can impair the function (via reduced resting-state cerebral blood flow) and structure (via formation of CMH) of the brain vasculature.

Conference Presentation

Citation Download Citation

Danny F. Xie, Christian Crouzet, Chuo Fang, Han Liu, Jihua Liu, Donghy Lee, Adrian Vallejo, Annlia Paganini-Hill, Wei Ling Lau, David Cribbs, Mark Fisher, and Bernard Choi "Hypertension provokes the development of cerebral microhemorrhages and vascular injury in a mouse model", Proc. SPIE PC12828, Neural Imaging and Sensing 2024, PC128280J (13 March 2024); https://doi.org/10.1117/12.3002206

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available