Intraoperative detection of glioma infiltration with attenuation-based quantitative OCT

Hyeon-Cheol Park; Defu Chen; Wu Yuan; David W. Nauen; Kaisorn Chaichana; Chetan Bettegowda; Alfredo Quiñones-Hinojosa; Xingde Li

doi:10.1117/12.3004223

19 March 2024 Intraoperative detection of glioma infiltration with attenuation-based quantitative OCT

Hyeon-Cheol Park, Defu Chen, Wu Yuan, David W. Nauen, Kaisorn Chaichana, Chetan Bettegowda, Alfredo Quiñones-Hinojosa, Xingde Li

Author Affiliations +

Proceedings Volume PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; PC128302G (2024) https://doi.org/10.1117/12.3004223
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

This study reports the results of our recent in vivo study using attenuation-based quantitative OCT for intra-operative mapping of brain cancer in patients. A total of 34 brain cancer patients were recruited, and an optimal optical attenuation threshold of 4.3 mm-1 was established with cancer of lower values. We achieved an excellent specificity of over 98%, with a corresponding sensitivity of over 95% for both high-grade and low-grade cancers. Applying the established optical attenuation threshold to infiltrated tissues, we were able to identify regions of cancers qualitatively matching the neuropathologist’s assessment. The study suggests that optical attenuation-based quantitative OCT represents a promising technology for intraoperative brain cancer detection and

Conference Presentation

Citation Download Citation

Hyeon-Cheol Park, Defu Chen, Wu Yuan, David W. Nauen, Kaisorn Chaichana, Chetan Bettegowda, Alfredo Quiñones-Hinojosa, and Xingde Li "Intraoperative detection of glioma infiltration with attenuation-based quantitative OCT", Proc. SPIE PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, PC128302G (19 March 2024); https://doi.org/10.1117/12.3004223

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Signal attenuation

Optical coherence tomography

Tissue optics

Brain cancer

Cancer detection

Cancer

Brain mapping

Show All Keywords

Keywords/Phrases

Search In:

Publication Years