Comparison of diffuse correlation spectroscopy, speckle contrast optical spectroscopy, and interferometric diffusing wave spectroscopy for blood flow monitoring

Joseph B. Majeski; Sang H. Chong; Nithin V. Ramachandran; Kenneth Abramson; Santosh Aparanji; Mingjun Zhao; Vivek J. Srinivasan; Wesley B. Baker; Arjun G. Yodh

doi:10.1117/12.3001284

13 March 2024 Comparison of diffuse correlation spectroscopy, speckle contrast optical spectroscopy, and interferometric diffusing wave spectroscopy for blood flow monitoring

Joseph B. Majeski, Sang H. Chong, Nithin V. Ramachandran, Kenneth Abramson, Santosh Aparanji, Mingjun Zhao, Vivek J. Srinivasan, Wesley B. Baker, Arjun G. Yodh

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Proceedings Volume PC12841, Dynamics and Fluctuations in Biomedical Photonics XXI; PC128410D (2024) https://doi.org/10.1117/12.3001284
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Diffuse correlation spectroscopy is a widely used optical technique for recovery of blood flow. Its applications have included monitoring of ischemia, blood flow in tumors, and cerebral blood flow. Recently, several variants on this technology have been developed with potential to enhance sensitivity to deep tissues, increase signal-to-noise ratio, and lower costs. Here, we employ diffuse correlation spectroscopy, speckle contrast optical spectroscopy, and interferometric diffusing wave spectroscopy concurrently to measure in vivo and in vitro flow. The results elucidate the advantages and disadvantages of each modality and will aid researchers in selecting a blood flow monitoring method for specific applications.

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Joseph B. Majeski, Sang H. Chong, Nithin V. Ramachandran, Kenneth Abramson, Santosh Aparanji, Mingjun Zhao, Vivek J. Srinivasan, Wesley B. Baker, and Arjun G. Yodh "Comparison of diffuse correlation spectroscopy, speckle contrast optical spectroscopy, and interferometric diffusing wave spectroscopy for blood flow monitoring", Proc. SPIE PC12841, Dynamics and Fluctuations in Biomedical Photonics XXI, PC128410D (13 March 2024); https://doi.org/10.1117/12.3001284

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KEYWORDS

Blood circulation

Spectroscopy

Optical spectroscopy

Optical sensing

Speckle

Speckle interferometry

Optical interferometry

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