Effects of nano-fractional laser treatment on cartilage structure and function

Tyler Iorizzo; Santana Wright; James Childs; Ilya Yaroslavsky; Gregory Altshuler; Anna N. Yaroslavsky

doi:10.1117/12.3010484

13 March 2024 Effects of nano-fractional laser treatment on cartilage structure and function

Tyler Iorizzo, Santana Wright, James Childs, Ilya Yaroslavsky, Gregory Altshuler, Anna N. Yaroslavsky

Proceedings Volume PC12841, Dynamics and Fluctuations in Biomedical Photonics XXI; PC128410J (2024) https://doi.org/10.1117/12.3010484
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

The goal of this study was to investigate how nano-channels created by laser irradiation can affect the diffusion properties of cartilage. Nano-channels were created using a 400 µm fiber optic and a 1550 nm laser. Optical polarization images confirmed the creation of nano-channels. Samples were placed in a homemade diffusion chamber, containing CuSO4 solution and distilled water in the donor and recipient chambers, respectively. T1 weighted MR images were taken over several time points and processed to analyze the rate of diffusion through each sample. Peak diffusion occurred at 24 hours for treated samples and 48 hours for native samples. At 24-hours, diffusion rate was approximately 50% higher in treated samples. At 72-hours, diffusion rate was 9% higher in treated samples. Our results highlight that laser treatment could improve treatment of diseases and injuries of cartilage. Optical confocal imaging is underway to investigate the microscopic morphology of the treated samples.

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Citation Download Citation

Tyler Iorizzo, Santana Wright, James Childs, Ilya Yaroslavsky, Gregory Altshuler, and Anna N. Yaroslavsky "Effects of nano-fractional laser treatment on cartilage structure and function", Proc. SPIE PC12841, Dynamics and Fluctuations in Biomedical Photonics XXI, PC128410J (13 March 2024); https://doi.org/10.1117/12.3010484

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KEYWORDS

Cartilage

Diffusion

Laser therapeutics

Permeability

Sampling rates

Laser irradiation

Vacuum chambers

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