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13 March 2024 Nanographene oxide synergizes with a novel biopolymer for localized ablative immunotherapy for cancer treatment
Coline Furrer, Trisha Valerio, Wei R. Chen
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Proceedings Volume PC12843, Biophotonics and Immune Responses XIX; PC128430E (2024) https://doi.org/10.1117/12.3001637
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Localized ablative immunotherapy (LAIT) combines targeted photothermal therapy (PTT) and immunotherapy to ablate the primary tumor site using laser irradiation while inducing systemic and specific anti-tumor immune responses for the treatment of metastatic cancers. The therapeutic efficiency of LAIT synergized with nanomedicine has been proven to be safe and effective for cancer treatment. Here, graphene oxide (GO) is used as a light-absorbing agent to enhance the generation of heat caused by PTT and increase its tumoricidal effect. GO is also a nanocarrier for drug delivery of the immune-stimulating biopolymer N-dihydrogalactochitosan (GC). GC is an innovative and effective immunostimulant/adjuvant with surfactant properties that was used to functionalize GO nanosheets. This work was designed to determine the main properties of GO/GC nanoparticles (NPs) when used in combination with PTT. The therapeutic efficacy of the treatment is being assessed on a highly aggressive and poorly immunogenic pancreatic tumor model in mice. Overall, GO/GC shows promising properties as a stable, safe, and effective photothermal agent and immunostimulant for nano-ablative immunotherapy for cancer.
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Coline Furrer, Trisha Valerio, and Wei R. Chen "Nanographene oxide synergizes with a novel biopolymer for localized ablative immunotherapy for cancer treatment", Proc. SPIE PC12843, Biophotonics and Immune Responses XIX, PC128430E (13 March 2024); https://doi.org/10.1117/12.3001637
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KEYWORDS
Tumors
Cancer
Oncology
Graphene
In vitro testing
Oxides
Ablation
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