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13 March 2024 Quantifying cerebral microvasculature alterations in neurodegenerative diseases
Mackenzie Hyman, Shuaibin Chang, Jairui Yang, Anna Novoseltseva, Gulce Küreli, Ann C. McKee, Irving J. Bigio, David A. Boas, Hui Wang
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Proceedings Volume PC12854, Label-free Biomedical Imaging and Sensing (LBIS) 2024; PC128540A (2024) https://doi.org/10.1117/12.3000090
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Cerebral microvascular alterations are increasingly recognized as important contributors to neurodegenerative diseases, such as Alzheimer's Disease (AD) and chronic traumatic encephalopathy (CTE). To characterize these changes, we used a custom serial-sectioning, polarization-sensitive optical coherence tomography system to collect volumetric images of brain tissue volumes from the dorsolateral frontal lobe of normal controls and subjects with pathologically confirmed AD and CTE. We performed vasculature segmentation on each tissue volume and then analyzed the geometric properties of the vascular networks. The preliminary results suggest reduced microvascular density in AD compared to both CTE and NC.
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(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.
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Mackenzie Hyman, Shuaibin Chang, Jairui Yang, Anna Novoseltseva, Gulce Küreli, Ann C. McKee, Irving J. Bigio, David A. Boas, and Hui Wang "Quantifying cerebral microvasculature alterations in neurodegenerative diseases", Proc. SPIE PC12854, Label-free Biomedical Imaging and Sensing (LBIS) 2024, PC128540A (13 March 2024); https://doi.org/10.1117/12.3000090
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KEYWORDS
Alzheimer's disease
Brain diseases
Biological samples
Control systems
Tissues
Brain tissue
Gaussian filters
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