Evaluation of cerebral microcirculation in a mouse model of systemic inflammation

Cong Zhang; Patrick Delafontaine-Martel; Frédéric Lesage

doi:10.1117/12.2692669

13 March 2024 Evaluation of cerebral microcirculation in a mouse model of systemic inflammation

Cong Zhang, Patrick Delafontaine-Martel, Frédéric Lesage

Proceedings Volume PC12856, Biomedical Applications of Light Scattering XIV; PC128560F (2024) https://doi.org/10.1117/12.2692669
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

The cerebral microcirculation plays a crucial role in maintaining cerebral homeostasis and facilitating optimal neuronal activity. Perturbations in this intricate microcirculatory system have been observed in neurological conditions such as Alzheimer's disease or systemic inflammation. However, changes occurring at the level of the capillary are difficult to translate to biomarkers that could be measured macroscopically. In this study, we employed a combined spectral optical coherence tomography (OCT) and intrinsic signal optical imaging (ISOI) system to investigate the capillary stalling and transit time of cerebral blood vessels in a mouse model of systemic inflammation induced by the intraperitoneal injection of lipopolysaccharide (LPS). Our findings reveal that LPS administration significantly increases both the percentage and duration of capillary stalling compared to mice receiving 0.9% saline injection. Moreover, LPS-induced mice exhibit significantly prolonged transit time of cerebral blood vessels compared to control mice. These observations suggest that capillary stalling, induced by inflammation, modulate transit time, a measure that has translational potential.

Conference Presentation

Citation Download Citation

Cong Zhang, Patrick Delafontaine-Martel, and Frédéric Lesage "Evaluation of cerebral microcirculation in a mouse model of systemic inflammation", Proc. SPIE PC12856, Biomedical Applications of Light Scattering XIV, PC128560F (13 March 2024); https://doi.org/10.1117/12.2692669

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Inflammation

Capillaries

Mouse models

Blood vessels

Optical coherence tomography

Intrinsic optical signal imaging

Modulation

Show All Keywords

Keywords/Phrases

Search In:

Publication Years