Spectral oximetry assessed with high-speed ultra-high-resolution optical coherence tomography

Larry E. Kagemann Jr.; Gadi Wollstein M.D.; Maciej Wojtkowski; Hiroshi Ishikawa M.D.; Kelly A. Townsend; Michelle L. Gabriele; Vivek Jay Srinivasan; James G. Fujimoto; Joel S. Schuman M.D.

doi:10.1117/1.2772655

1 July 2007 Spectral oximetry assessed with high-speed ultra-high-resolution optical coherence tomography

Larry E. Kagemann Jr., Gadi Wollstein M.D., Maciej Wojtkowski, Hiroshi Ishikawa M.D., Kelly A. Townsend, Michelle L. Gabriele, Vivek Jay Srinivasan, James G. Fujimoto, Joel S. Schuman M.D.

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Journal of Biomedical Optics, Vol. 12, Issue 4, 041212 (July 2007). https://doi.org/10.1117/1.2772655

Abstract

We use Fourier domain optical coherence tomography (OCT) data to assess retinal blood oxygen saturation. Three-dimensional disk-centered retinal tissue volumes were assessed in 17 normal healthy subjects. After removing DC and low-frequency a-scan components, an OCT fundus image was created by integrating total reflectance into a single reflectance value. Thirty fringe patterns were sampled; 10 each from the edge of an artery, adjacent tissue, and the edge of a vein, respectively. A-scans were recalculated, zeroing the DC term in the power spectrum, and used for analysis. Optical density ratios (ODRs) were calculated as ODR_Art=ln(Tissue₈₅₅/Art₈₅₅)/ln(Tissue₈₀₅/Art₈₀₅) and ODRVein=ln(Tissue₈₅₅/Vein₈₅₅)/ln(Tissue₈₀₅/Vein₈₀₅) with Tissue, Art, and Vein representing total a-scan reflectance at the 805- or 855-nm centered bandwidth. Arterial and venous ODRs were compared by the Wilcoxon signed rank test. Arterial ODRs were significantly greater than venous ODRs (1.007±2.611 and -1.434±4.310, respectively; p=0.0217) (mean±standard deviation). A difference between arterial and venous blood saturation was detected. This suggests that retinal oximetry may possibly be added as a metabolic measurement in structural imaging devices.

©(2007) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Larry E. Kagemann Jr., Gadi Wollstein M.D., Maciej Wojtkowski, Hiroshi Ishikawa M.D., Kelly A. Townsend, Michelle L. Gabriele, Vivek Jay Srinivasan, James G. Fujimoto, and Joel S. Schuman M.D. "Spectral oximetry assessed with high-speed ultra-high-resolution optical coherence tomography," Journal of Biomedical Optics 12(4), 041212 (1 July 2007). https://doi.org/10.1117/1.2772655

Published: 1 July 2007

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