Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging

Chulhong Kim; Ruogu Qin; Jeff S. Xu; Lihong V. Wang; Ronald X. Xu

doi:10.1117/1.3302808

1 January 2010 Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging

Chulhong Kim, Ruogu Qin, Jeff S. Xu, Lihong V. Wang, Ronald X. Xu

Author Affiliations +

Journal of Biomedical Optics, Vol. 15, Issue 1, 010510 (January 2010). https://doi.org/10.1117/1.3302808

Abstract

We develop a novel dual-modal contrast agent-encapsulated-ink poly(lactic-co-glycolic acid) (PLGA) microbubbles and nanobubbles-for photoacoustic and ultrasound imaging. Soft gelatin phantoms with embedded tumor simulators of encapsulated-ink PLGA microbubbles and nanobubbles in various concentrations are clearly shown in both photoacoustic and ultrasound images. In addition, using photoacoustic imaging, we successfully image the samples positioned below 1.8-cm-thick chicken breast tissues. Potentially, simultaneous photoacoustic and ultrasound imaging enhanced by encapsulated-dye PLGA microbubbles or nanobubbles can be a valuable tool for intraoperative assessment of tumor boundaries and therapeutic margins.

©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Chulhong Kim, Ruogu Qin, Jeff S. Xu, Lihong V. Wang, and Ronald X. Xu "Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging," Journal of Biomedical Optics 15(1), 010510 (1 January 2010). https://doi.org/10.1117/1.3302808

Published: 1 January 2010

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