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3 June 2013 En face parametric imaging of tissue birefringence using polarization-sensitive optical coherence tomography
Lixin Chin, Xiaojie Yang, Robert A. McLaughlin, Peter B. Noble, David D. Sampson
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Journal of Biomedical Optics, Vol. 18, Issue 6, 066005 (June 2013). https://doi.org/10.1117/1.JBO.18.6.066005
Abstract
A technique for generating en face parametric images of tissue birefringence from scans acquired using a fiber-based polarization-sensitive optical coherence tomography (PS-OCT) system utilizing only a single-incident polarization state is presented. The value of birefringence is calculated for each A-scan in the PS-OCT volume using a quadrature demodulation and phase unwrapping algorithm. The algorithm additionally uses weighted spatial averaging and weighted least squares regression to account for the variation in phase accuracies due to varying OCT signal-to-noise-ratio. The utility of this technique is demonstrated using a model of thermally induced damage in porcine tendon and validated against histology. The resulting en face images of tissue birefringence are more useful than conventional PS-OCT B-scans in assessing the severity of tissue damage and in localizing the spatial extent of damage.
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2013/$25.00 © 2013 SPIE
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Lixin Chin, Xiaojie Yang, Robert A. McLaughlin, Peter B. Noble, and David D. Sampson "En face parametric imaging of tissue birefringence using polarization-sensitive optical coherence tomography," Journal of Biomedical Optics 18(6), 066005 (3 June 2013). https://doi.org/10.1117/1.JBO.18.6.066005
Published: 3 June 2013
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KEYWORDS
Birefringence
Optical coherence tomography
Tissues
Tissue optics
Polarization
Signal to noise ratio
Imaging systems
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