Lateral and axial measurement differences between spectral-domain optical coherence tomography systems

Francisco A. Folgar; Eric L. Yuan; Sina Farsiu; Cynthia A. Toth

doi:10.1117/1.JBO.19.1.016014

17 January 2014 Lateral and axial measurement differences between spectral-domain optical coherence tomography systems

Francisco A. Folgar, Eric L. Yuan, Sina Farsiu, Cynthia A. Toth

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Journal of Biomedical Optics, Vol. 19, Issue 1, 016014 (January 2014). https://doi.org/10.1117/1.JBO.19.1.016014

Abstract

We assessed the reproducibility of lateral and axial measurements performed with spectral-domain optical coherence tomography (SDOCT) instruments from a single manufacturer and across several manufacturers. One human retina phantom was imaged on two instruments each from four SDOCT platforms: Zeiss Cirrus, Heidelberg Spectralis, Bioptigen SDOIS, and hand-held Bioptigen Envisu. Built-in software calipers were used to perform manual measurements of a fixed lateral width (LW), central foveal thickness (CFT), and parafoveal thickness (PFT) 1 mm from foveal center. Inter- and intraplatform reproducibilities were assessed with analysis of variance and Tukey-Kramer tests. The range of measurements between platforms was 5171 to 5290 μm for mean LW (p<0.001), 162 to 196 μm for mean CFT (p<0.001), and 267 to 316 μm for mean PFT (p<0.001). All SDOCT platforms had significant differences between each other for all measurements, except LW between Bioptigen SDOIS and Envisu (p=0.27). Intraplatform differences were significantly smaller than interplatform differences for LW (p=0.020), CFT (p=0.045), and PFT (p=0.004). Conversion factors were generated for lateral and axial scaling between SDOCT platforms. Lateral and axial manual measurements have greater variance across different SDOCT platforms than between instruments from the same platform. Conversion factors for measurements from different platforms can produce normalized values for patient care and clinical studies.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Francisco A. Folgar, Eric L. Yuan, Sina Farsiu, and Cynthia A. Toth "Lateral and axial measurement differences between spectral-domain optical coherence tomography systems," Journal of Biomedical Optics 19(1), 016014 (17 January 2014). https://doi.org/10.1117/1.JBO.19.1.016014

Published: 17 January 2014

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