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10 August 2016 In vivo white light and contrast-enhanced vital-dye fluorescence imaging of Barrett’s-related neoplasia in a single-endoscopic insertion
Yubo Tang, Jennifer Carns, Alexandros D. Polydorides, Sharmila Anandasabapathy M.D., Rebecca R. Richards-Kortum
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Journal of Biomedical Optics, Vol. 21, Issue 8, 086004 (August 2016). https://doi.org/10.1117/1.JBO.21.8.086004
Abstract
A modular video endoscope is developed to enable both white light imaging (WLI) and vital-dye fluorescence imaging (VFI) in a single-endoscopic insertion for the early detection of cancer in Barrett’s esophagus (BE). We demonstrate that VFI can be achieved in conjunction with white light endoscopy, where appropriate white balance is used to correct for the presence of the emission filter. In VFI mode, a contrast enhancement feature is implemented in real time to further highlight glandular patterns in BE and related malignancies without introducing artifacts. In a pilot study, we demonstrate accurate correlation of images in two widefield modalities, with representative images showing the disruption and effacement of glandular architecture associated with cancer development in BE. VFI images of these alterations exhibit enhanced contrast when compared to WLI. Results suggest that the usefulness of VFI in the detection of BE-related neoplasia should be further evaluated in future in vivo studies.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Yubo Tang, Jennifer Carns, Alexandros D. Polydorides, Sharmila Anandasabapathy M.D., and Rebecca R. Richards-Kortum "In vivo white light and contrast-enhanced vital-dye fluorescence imaging of Barrett’s-related neoplasia in a single-endoscopic insertion," Journal of Biomedical Optics 21(8), 086004 (10 August 2016). https://doi.org/10.1117/1.JBO.21.8.086004
Published: 10 August 2016
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Cited by 2 scholarly publications.
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KEYWORDS
In vivo imaging
Luminescence
Endoscopy
Endoscopes
Cancer
Imaging systems
Semiconductor lasers
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