False positives and false negatives in functional near-infrared spectroscopy: issues, challenges, and the way forward

Ilias Tachtsidis; Felix Scholkmann

doi:10.1117/1.NPh.3.3.031405

9 March 2016 False positives and false negatives in functional near-infrared spectroscopy: issues, challenges, and the way forward

Ilias Tachtsidis, Felix Scholkmann

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Neurophotonics, Vol. 3, Issue 3, 031405 (March 2016). https://doi.org/10.1117/1.NPh.3.3.031405

Abstract

We highlight a significant problem that needs to be considered and addressed when performing functional near-infrared spectroscopy (fNIRS) studies, namely the possibility of inadvertently measuring fNIRS hemodynamic responses that are not due to neurovascular coupling. These can be misinterpreted as brain activity, i.e., “false positives” (errors caused by wrongly assigning a detected hemodynamic response to functional brain activity), or mask brain activity, i.e., “false negatives” (errors caused by wrongly assigning a not observed hemodynamic response in the presence of functional brain activity). Here, we summarize the possible physiological origins of these issues and suggest ways to avoid and remove them.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Ilias Tachtsidis and Felix Scholkmann "False positives and false negatives in functional near-infrared spectroscopy: issues, challenges, and the way forward," Neurophotonics 3(3), 031405 (9 March 2016). https://doi.org/10.1117/1.NPh.3.3.031405

Published: 9 March 2016

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