Raghunandan Hills Reserve is an important protected area in Bangladesh that supports some remnant patches of natural forest and is the habitat of several globally threatened primates including Western Hoolock Gibbon, Northern Pig-tailed Macaque, and Capped Langur. However, deforestation and forest degradation due to anthropogenic factors, such as illegal logging and fuelwood collection are age-old problems at Raghunandan. The areas of the reserve vulnerable to future conversions due to the possible proximate or underlaying causes were unknown. This study analyzed the historical trend of forest and land-use/landcover transitions at Raghunandan Hills Reserve from 1995 until 2015 at a 10-year interval using Monte Carlo spectral unmixing and knowledge-based classification approaches to Landsat satellite images in Claslite and ArcGIS software. Based on the past trend, it then predicted the future trend of forest land-use/landcover transitions for 2025 and 2035 using an artificial multi-layer perceptron neural network with Markov Chain machine learning algorithm integrated into the land change modeler module of IDRISI/TerrSet software. Results indicated that ∼30  %   to 35% of the total area of the reserve was covered by forest, which included patches of natural forest and plantations, whereas the remaining area was occupied by non-forest categories like scattered degraded forests, grasses, and shrubs. Forest cover declined during 1995–2005, and then increased slightly during 2005–2015 due to afforestation activities. This trend is likely to continue in the future with forest cover occupying nearly 40% of the reserve by 2025 and 2035. Along with identifying the areas where the forest is likely to be expanded, the areas of the reserve vulnerable to deforestation (hotspots) were also highlighted and quantified in the form of maps and statistics. The findings have useful implications for any forest conservation initiatives including the global climate change mitigation program reducing emissions from deforestation and forest degradation+, which requires identifying at-risk areas of planned and unplanned deforestation.