Two-photon absorption-controlled multidose drug release: a novel approach for secondary cataract treatment

Hee-Cheol Kim; Sebastian Härtner; Martin Behe; Thomas M. Behr; Norbert A. Hampp

doi:10.1117/1.2209564

1 May 2006 Two-photon absorption-controlled multidose drug release: a novel approach for secondary cataract treatment

Hee-Cheol Kim, Sebastian Härtner, Martin Behe, Thomas M. Behr, Norbert A. Hampp

Author Affiliations +

Journal of Biomedical Optics, Vol. 11, Issue 3, 034024 (May 2006). https://doi.org/10.1117/1.2209564

Abstract

Tens of millions of cataract surgeries are done every year and the number is increasing heavily. Posterior capsule opacification is the major postoperative complication with an incidence of 10 to 50% within 5 years, depending on the age of the patient. We present a novel approach for secondary cataract treatment in a noninvasive manner. Photochemically triggered drug release from a polymer enables repeated drug applications for cataract treatment years after implantation of the intraocular lens, just when needed. However, light in the visible spectral range must pass through the lens but must not induce drug release. We demonstrate that two-photon absorption photochemistry is a powerful tool to overcome this problem. With wavelengths in the visible regime, a photochemical reaction that requires energies in the UV is triggered. The high intensities needed for this process never occur in any lighting condition in daily lives, but may be easily obtained with focused laser beams routinely used in ophthalmology. The properties of the therapeutic system are specified and the function is demonstrated by in-vitro cell tests. Noninvasive multidose photochemically triggered drug release from implanted intraocular lenses carrying a drug depot may be a therapeutic as well as an economic choice to established treatments of secondary cataracts.

©(2006) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Hee-Cheol Kim, Sebastian Härtner, Martin Behe, Thomas M. Behr, and Norbert A. Hampp "Two-photon absorption-controlled multidose drug release: a novel approach for secondary cataract treatment," Journal of Biomedical Optics 11(3), 034024 (1 May 2006). https://doi.org/10.1117/1.2209564

Published: 1 May 2006

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KEYWORDS

Polymers

Absorption

Polymer thin films

Ultraviolet radiation

Visible radiation

In vitro testing

Polymethylmethacrylate

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