Optical imaging of alpha emitters: simulations, phantom, and in vivo results

Federico Boschi; Andrea Sbarbati; Sergio Lo Meo; Pier Luca Rossi; Riccardo Calandrino; Antonello E. Spinelli

doi:10.1117/1.3663441

1 December 2011 Optical imaging of alpha emitters: simulations, phantom, and in vivo results

Federico Boschi, Andrea Sbarbati, Sergio Lo Meo, Pier Luca Rossi, Riccardo Calandrino, Antonello E. Spinelli

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Journal of Biomedical Optics, Vol. 16, Issue 12, 126011 (December 2011). https://doi.org/10.1117/1.3663441

Abstract

There has been growing interest in investigating both the in vitro and in vivo detection of optical photons from a plethora of beta emitters using optical techniques. In this paper we have investigated an alpha particle induced fluorescence signal by using a commercial CCD-based small animal optical imaging system. The light emission of a ²⁴¹Am source was simulated using GEANT4 and tested in different experimental conditions including the imaging of in vivo tissue. We believe that the results presented in this work can be useful to describe a possible mechanism for the in vivo detection of alpha emitters used for therapeutic purposes.

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Federico Boschi, Andrea Sbarbati, Sergio Lo Meo, Pier Luca Rossi, Riccardo Calandrino, and Antonello E. Spinelli "Optical imaging of alpha emitters: simulations, phantom, and in vivo results," Journal of Biomedical Optics 16(12), 126011 (1 December 2011). https://doi.org/10.1117/1.3663441

Published: 1 December 2011

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