Temperature-modulated fluorescence tomography based on both concentration and lifetime contrast

Yuting Lin; Tiffany C. Kwong; Gultekin Gulsen; Linden Bolisay

doi:10.1117/1.JBO.17.5.056007

4 May 2012 Temperature-modulated fluorescence tomography based on both concentration and lifetime contrast

Yuting Lin, Tiffany C. Kwong, Gultekin Gulsen, Linden Bolisay

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Journal of Biomedical Optics, Vol. 17, Issue 5, 056007 (May 2012). https://doi.org/10.1117/1.JBO.17.5.056007

Abstract

It is challenging to image fluorescence objects with high spatial resolution in a highly scattering medium. Recently reported temperature-sensitive indocyanine green-loaded pluronic nanocapsules can potentially alleviate this problem. Here we demonstrate a frequency-domain temperature-modulated fluorescence tomography system that could acquire images at high intensity-focused ultrasound resolution with use of these nanocapsules. The system is experimentally verified with a phantom study, where a 3-mm fluorescence object embedded 2 cm deep in a turbid medium is successfully recovered based on both intensity and lifetime contrast.

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Yuting Lin, Tiffany C. Kwong, Gultekin Gulsen, and Linden Bolisay "Temperature-modulated fluorescence tomography based on both concentration and lifetime contrast," Journal of Biomedical Optics 17(5), 056007 (4 May 2012). https://doi.org/10.1117/1.JBO.17.5.056007

Published: 4 May 2012

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