Micro-computed tomography-guided, non-equal voxel Monte Carlo method for reconstruction of fluorescence molecular tomography

Guotao Quan; Kan Wang; Xiaoquan Yang; Yong Deng; Qingming Luo; Hui Gong

doi:10.1117/1.JBO.17.8.086006

8 August 2012 Micro-computed tomography-guided, non-equal voxel Monte Carlo method for reconstruction of fluorescence molecular tomography

Guotao Quan, Kan Wang, Xiaoquan Yang, Yong Deng, Qingming Luo, Hui Gong

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Journal of Biomedical Optics, Vol. 17, Issue 8, 086006 (August 2012). https://doi.org/10.1117/1.JBO.17.8.086006

Abstract

The study of dual-modality technology which combines microcomputed tomography (micro-CT) and fluorescence molecular tomography (FMT) has become one of the main focuses in FMT. However, because of the diversity of the optical properties and irregular geometry for small animals, a reconstruction method that can effectively utilize the high-resolution structural information of micro-CT for tissue with arbitrary optical properties is still one of the most challenging problems in FMT. We develop a micro-CT-guided non-equal voxel Monte Carlo method for FMT reconstruction. With the guidance of micro-CT, precise voxel binning can be conducted on the irregular boundary or region of interest. A modified Laplacian regularization method is also proposed to accurately reconstruct the distribution of the fluorescent yield for non-equal space voxels. Simulations and phantom experiments show that this method not only effectively reduces the loss of high-resolution structural information of micro-CT in irregular boundaries and increases the accuracy of the FMT algorithm in both forward and inverse problems, but the method also has a small Jacobian matrix and a short reconstruction time. At last, we performed small animal imaging to validate our method.

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Guotao Quan, Kan Wang, Xiaoquan Yang, Yong Deng, Qingming Luo, and Hui Gong "Micro-computed tomography-guided, non-equal voxel Monte Carlo method for reconstruction of fluorescence molecular tomography," Journal of Biomedical Optics 17(8), 086006 (8 August 2012). https://doi.org/10.1117/1.JBO.17.8.086006

Published: 8 August 2012

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