Objective-free optical-resolution photoacoustic microscopy

Chulhong Kim; Sung-Jo Park; Jongki Kim; Sungrae Lee; Changho Lee; Mansik Jeon; Jeehyun Kim; Kyunghwan K. Oh

doi:10.1117/1.JBO.18.1.010501

11 December 2012 Objective-free optical-resolution photoacoustic microscopy

Chulhong Kim, Sung-Jo Park, Jongki Kim, Sungrae Lee, Changho Lee, Mansik Jeon, Jeehyun Kim, Kyunghwan K. Oh

Author Affiliations +

Journal of Biomedical Optics, Vol. 18, Issue 1, 010501 (December 2012). https://doi.org/10.1117/1.JBO.18.1.010501

Abstract

Optical-resolution photoacoustic microscopy (OR-PAM) becomes a premier microscopic imaging tool in biomedicine because it provides agent-free optical absorption information in tissues. By tightly focusing light to a spot, a significantly improved lateral resolution can be achieved in OR-PAM. The focal spot size is typically determined by the numerical aperture of the used objective lens. Here, we demonstrate objective-free OR-PAM using a fiber optic Bessel beam generator. In this approach, no objective lens is required and, beneficially, the complexities of conventional OR-PAM systems can be greatly relieved. We have obtained photoacoustic images of a carbon fiber with a diameter of ~ 6 μm, whose lateral resolution was measured to be better than 6 to 7 μm.

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Chulhong Kim, Sung-Jo Park, Jongki Kim, Sungrae Lee, Changho Lee, Mansik Jeon, Jeehyun Kim, and Kyunghwan K. Oh "Objective-free optical-resolution photoacoustic microscopy," Journal of Biomedical Optics 18(1), 010501 (11 December 2012). https://doi.org/10.1117/1.JBO.18.1.010501

Published: 11 December 2012

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Cited by 24 scholarly publications.

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KEYWORDS

Carbon

Bessel beams

Biomedical optics

Photoacoustic microscopy

Image resolution

Tissue optics

In vivo imaging

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