Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans

Brendan F. Kennedy; Francisco Gomes Malheiro; Lixin Chin; David D. Sampson

doi:10.1117/1.JBO.19.7.076006

7 July 2014 Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans

Brendan F. Kennedy, Francisco Gomes Malheiro, Lixin Chin, David D. Sampson

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Journal of Biomedical Optics, Vol. 19, Issue 7, 076006 (July 2014). https://doi.org/10.1117/1.JBO.19.7.076006

Abstract

We present an acquisition method for optical coherence elastography (OCE) that enables acquisition of three-dimensional elastograms in 5 s, an order of magnitude faster than previously reported. In this method, based on compression elastography, the mechanical load applied to the sample is altered between acquisitions of consecutive optical coherence tomography volume scans (C-scans). The voxel-by-voxel phase difference between the volumes is used to determine the axial displacement and determining the gradient of the axial displacement versus depth gives the local axial strain. We demonstrate sub-100-microstrain sensitivity and high contrast in elastograms, acquired in 5 s, of structured phantoms and freshly excised rat muscle tissue that are comparable in strain sensitivity and dynamic range to our previously reported B-scan-based method. The much higher acquisition speed may expedite the translation of OCE to clinical and in vivo applications.

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Brendan F. Kennedy, Francisco Gomes Malheiro, Lixin Chin, and David D. Sampson "Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans," Journal of Biomedical Optics 19(7), 076006 (7 July 2014). https://doi.org/10.1117/1.JBO.19.7.076006

Published: 7 July 2014

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