Three-dimensional fuse deposition modeling of tissue-simulating phantom for biomedical optical imaging

Erbao Dong; Zuhua Zhao; Minjie Wang; Yanjun Xie; Shidi Li; Pengfei Shao; Liuquan Cheng; Ronald X. Xu

doi:10.1117/1.JBO.20.12.121311

25 November 2015 Three-dimensional fuse deposition modeling of tissue-simulating phantom for biomedical optical imaging

Erbao Dong, Zuhua Zhao, Minjie Wang, Yanjun Xie, Shidi Li, Pengfei Shao, Liuquan Cheng, Ronald X. Xu

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Journal of Biomedical Optics, Vol. 20, Issue 12, 121311 (November 2015). https://doi.org/10.1117/1.JBO.20.12.121311

Abstract

Biomedical optical devices are widely used for clinical detection of various tissue anomalies. However, optical measurements have limited accuracy and traceability, partially owing to the lack of effective calibration methods that simulate the actual tissue conditions. To facilitate standardized calibration and performance evaluation of medical optical devices, we develop a three-dimensional fuse deposition modeling (FDM) technique for freeform fabrication of tissue-simulating phantoms. The FDM system uses transparent gel wax as the base material, titanium dioxide (TiO₂) powder as the scattering ingredient, and graphite powder as the absorption ingredient. The ingredients are preheated, mixed, and deposited at the designated ratios layer-by-layer to simulate tissue structural and optical heterogeneities. By printing the sections of human brain model based on magnetic resonance images, we demonstrate the capability for simulating tissue structural heterogeneities. By measuring optical properties of multilayered phantoms and comparing with numerical simulation, we demonstrate the feasibility for simulating tissue optical properties. By creating a rat head phantom with embedded vasculature, we demonstrate the potential for mimicking physiologic processes of a living system.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Erbao Dong, Zuhua Zhao, Minjie Wang, Yanjun Xie, Shidi Li, Pengfei Shao, Liuquan Cheng, and Ronald X. Xu "Three-dimensional fuse deposition modeling of tissue-simulating phantom for biomedical optical imaging," Journal of Biomedical Optics 20(12), 121311 (25 November 2015). https://doi.org/10.1117/1.JBO.20.12.121311

Published: 25 November 2015

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