CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 22 > Issue 2 > Article
Open Access
10 February 2017 Evaluation of singlet oxygen explicit dosimetry for predicting treatment outcomes of benzoporphyrin derivative monoacid ring A-mediated photodynamic therapy
Michele M. Kim, Rozhin Penjweini, Timothy C. Zhu
Author Affiliations +
Journal of Biomedical Optics, Vol. 22, Issue 2, 028002 (February 2017). https://doi.org/10.1117/1.JBO.22.2.028002
Abstract
Existing dosimetric quantities do not fully account for the dynamic interactions between the key components of photodynamic therapy (PDT) or the varying PDT oxygen consumption rates for different fluence rates. Using a macroscopic model, reacted singlet oxygen ( [ O 2 1 ] rx ) was calculated and evaluated for its effectiveness as a dosimetric metric for PDT outcome. Mice bearing radiation-induced fibrosarcoma tumors were treated with benzoporphyrin derivative monoacid ring A (BPD) at a drug-light interval of 3 h with various in-air fluences (30 to 350    J / cm 2 ) and in-air fluence rates (50 to 150    mW / cm 2 ). Explicit measurements of BPD concentration and tissue optical properties were performed and used to calculate [ O 2 1 ] rx , photobleaching ratio, and PDT dose. For four mice, in situ measurements of O 2
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2017/$25.00 © 2017 SPIE
Citation Download Citation
Michele M. Kim, Rozhin Penjweini, and Timothy C. Zhu "Evaluation of singlet oxygen explicit dosimetry for predicting treatment outcomes of benzoporphyrin derivative monoacid ring A-mediated photodynamic therapy," Journal of Biomedical Optics 22(2), 028002 (10 February 2017). https://doi.org/10.1117/1.JBO.22.2.028002
Received: 16 December 2016; Accepted: 24 January 2017; Published: 10 February 2017
JOURNAL ARTICLE
 10 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 25 scholarly publications.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Photodynamic therapy
Oxygen
Tumors
Tissue optics
Optical properties
In vivo imaging
Luminescence
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top