Laser absorption spectroscopy measurements of different pulmonary oxygen gas concentrations in transmittance and remittance geometry: phantom study

Andrea Pacheco; Jean Matias; Konstantin Grygoryev; Martin Hansson; Sara Bergsten; Stefan Andersson-Engels

doi:10.1117/1.JBO.28.11.115003

30 November 2023 Laser absorption spectroscopy measurements of different pulmonary oxygen gas concentrations in transmittance and remittance geometry: phantom study

Andrea Pacheco, Jean Matias, Konstantin Grygoryev, Martin Hansson, Sara Bergsten, Stefan Andersson-Engels

Author Affiliations +

Journal of Biomedical Optics, Vol. 28, Issue 11, 115003 (November 2023). https://doi.org/10.1117/1.JBO.28.11.115003

Abstract

Significance

The gas in scattering media absorption spectroscopy (GASMAS) technique has the potential for continuous, clinical monitoring of preterm infant lung function, removing the need for X-ray diagnosis and reliance on indirect and relatively slow measurement of blood oxygenation.

Aim

We aim to determine the optimal source–detector configuration for reliable pathlength calculation and to estimate the oxygen gas concentration inside the lung cavities filled with humidified gas with four different oxygen gas concentrations ranging between 21% and 100%.

Approach

Anthropomorphic optical phantoms of neonatal thorax with two different geometries were used to acquire GASMAS signals, for 30 source–detector configurations in transmittance and remittance geometry of phantoms in two sizes.

Results

The results show that an internal light administration is more likely to provide a high GASMAS signal-to-noise ratio (SNR). In general, better SNRs were obtained with the smaller set of phantoms. The values of pathlength and O₂ concentrations calculated with signals from the phantoms with optical properties at 820 nm exhibit higher variations than signals from the phantoms with optical properties at 764 nm.

Conclusion

Our study shows that, by moving the source and detector over the thorax, most of the lung volumes can potentially be assessed using the GASMAS technique.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

Citation Download Citation

Andrea Pacheco, Jean Matias, Konstantin Grygoryev, Martin Hansson, Sara Bergsten, and Stefan Andersson-Engels "Laser absorption spectroscopy measurements of different pulmonary oxygen gas concentrations in transmittance and remittance geometry: phantom study," Journal of Biomedical Optics 28(11), 115003 (30 November 2023). https://doi.org/10.1117/1.JBO.28.11.115003

Received: 25 April 2023; Accepted: 3 November 2023; Published: 30 November 2023

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
9 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Lung

Sensors

Oxygen

Absorption spectroscopy

Tissues

Absorption

Optical properties

Significance

Aim

Approach

Results

Conclusion

Show All Keywords

Keywords/Phrases

Search In:

Publication Years