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28 November 2023 Fast and robust Fourier ptychographic microscopy with position misalignment correction
Zicong Luo, Ruofei Wu, Hanbao Chen, Junrui Zhen, Mingdi Liu, Haiqi Zhang, Jiaxiong Luo, Dingan Han, Lisong Yan, Yanxiong Wu
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Journal of Biomedical Optics, Vol. 28, Issue 11, 116503 (November 2023). https://doi.org/10.1117/1.JBO.28.11.116503
Abstract

Significance

Fourier ptychographic microscopy (FPM) is a new, developing computational imaging technology. It can realize the quantitative phase imaging of a wide field of view and high-resolution (HR) simultaneously by means of multi-angle illumination via a light emitting diode (LED) array, combined with a phase recovery algorithm and the synthetic aperture principle. However, in the FPM reconstruction process, LED position misalignment affects the quality of the reconstructed image, and the reconstruction efficiency of the existing LED position correction algorithms needs to be improved.

Aim

This study aims to improve the FPM correction method based on simulated annealing (SA) and proposes a position misalignment correction method (AA-C algorithm) using an improved phase recovery strategy.

Approach

The spectrum function update strategy was optimized by adding an adaptive control factor, and the reconstruction efficiency of the algorithm was improved.

Results

The experimental results show that the proposed method is effective and robust for position misalignment correction of LED arrays in FPM, and the convergence speed can be improved by 21.2% and 54.9% compared with SC-FPM and PC-FPM, respectively.

Conclusions

These results can reduce the requirement of the FPM system for LED array accuracy and improve robustness.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Zicong Luo, Ruofei Wu, Hanbao Chen, Junrui Zhen, Mingdi Liu, Haiqi Zhang, Jiaxiong Luo, Dingan Han, Lisong Yan, and Yanxiong Wu "Fast and robust Fourier ptychographic microscopy with position misalignment correction," Journal of Biomedical Optics 28(11), 116503 (28 November 2023). https://doi.org/10.1117/1.JBO.28.11.116503
Received: 18 August 2023; Accepted: 13 November 2023; Published: 28 November 2023
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KEYWORDS
Reconstruction algorithms
Image restoration
Light emitting diodes
Lawrencium
Image quality
Image processing
Microscopy
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