Customizable optical tissue phantom platform for characterization of fluorescence imaging device sensitivity

Christopher Gibson; Arcturus Phoon; Ralph S. DaCosta

doi:10.1117/1.JBO.28.8.086004

30 August 2023 Customizable optical tissue phantom platform for characterization of fluorescence imaging device sensitivity

Christopher Gibson, Arcturus Phoon, Ralph S. DaCosta

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Journal of Biomedical Optics, Vol. 28, Issue 8, 086004 (August 2023). https://doi.org/10.1117/1.JBO.28.8.086004

Abstract

Significance

Optical tissue phantoms serve as inanimate and stable reference materials used to calibrate, characterize, standardize, and test biomedical imaging instruments. Although various types of solid tissue phantoms have been described in the literature, current phantom models are limited in that they do not have a depth feature that can be adjusted in real-time, they cannot be adapted to other applications, and their fabrication can be laborious and costly.

Aim

Our goal was to develop an optical phantom that could assess the imaging performance of fluorescence imaging devices and be customizable for different applications.

Approach

We developed a phantom with three distinct components, each of which can be customized.

Results

We present a method for fabricating a solid optical tissue that contains (1) an adjustable depth capability using thin film phantoms, (2) a refillable chip loaded with fluorophores of the user’s choice in various desired quantities, and (3) phantom materials representative of different tissue types.

Conclusions

This article describes the development of phantom models that are customizable, adaptable, and easy to design and fabricate.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Christopher Gibson, Arcturus Phoon, and Ralph S. DaCosta "Customizable optical tissue phantom platform for characterization of fluorescence imaging device sensitivity," Journal of Biomedical Optics 28(8), 086004 (30 August 2023). https://doi.org/10.1117/1.JBO.28.8.086004

Received: 3 May 2023; Accepted: 15 August 2023; Published: 30 August 2023

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KEYWORDS

Tissues

Fluorophores

Breast

Imaging devices

Adipose tissue

Connective tissue

Tissue optics

Significance

Aim

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