Light-scattering instrument to detect thromboemboli in blood

Kenneth Solen; Sivaprasad Sukavaneshvar; Yu Zheng; Brian Hanrahan; Matthew Hall; Paul Goodman; Benjamin Goodman; Fazal Mohammad

doi:10.1117/1.1527934

1 January 2003 Light-scattering instrument to detect thromboemboli in blood

Kenneth Solen, Sivaprasad Sukavaneshvar, Yu Zheng, Brian Hanrahan, Matthew Hall, Paul Goodman, Benjamin Goodman, Fazal Mohammad

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Journal of Biomedical Optics, Vol. 8, Issue 1, (January 2003). https://doi.org/10.1117/1.1527934

The characteristics and capabilities of a light-scattering microemboli detector (LSMD) are delineated by detailing its state-of-the-art configuration, by discussing the theoretical and empirical aspects of instrument calibration, and by summarizing various experimental studies that have benefited from this instrument. In the past, thromboembolism, which often results when blood contacts medical devices, has eluded scientific scrutiny due to the absence of instruments that could detect and quantify thromboemboli in circulating blood. More recently, the ability of the LSMD to provide continuous, noninvasive detection of thromboemboli in whole blood (meaning that the LSMD probe does not contact the blood) was exploited in various in vitro and ex vivo models to explore thromboembolic phenomena. Through this work, the LSMD evolved as a sensitive and an economical research tool for the study of thromboembolic phenomena.

©(2003) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Kenneth Solen, Sivaprasad Sukavaneshvar, Yu Zheng, Brian Hanrahan, Matthew Hall, Paul Goodman, Benjamin Goodman, and Fazal Mohammad "Light-scattering instrument to detect thromboemboli in blood," Journal of Biomedical Optics 8(1), (1 January 2003). https://doi.org/10.1117/1.1527934

Published: 1 January 2003

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