Greater contribution of cerebral than extracerebral hemodynamics to near-infrared spectroscopy signals for functional activation and resting-state connectivity in infants

Tsukasa Funane; Fumitaka Homae; Hama Watanabe; Masashi Kiguchi; Gentaro Taga

doi:10.1117/1.NPh.1.2.025003

2 September 2014 Greater contribution of cerebral than extracerebral hemodynamics to near-infrared spectroscopy signals for functional activation and resting-state connectivity in infants

Tsukasa Funane, Fumitaka Homae, Hama Watanabe, Masashi Kiguchi, Gentaro Taga

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Neurophotonics, Vol. 1, Issue 2, 025003 (September 2014). https://doi.org/10.1117/1.NPh.1.2.025003

Abstract

While near-infrared spectroscopy (NIRS) has been increasingly applied to neuroimaging and functional connectivity studies in infants, it has not been quantitatively examined as to what extent the deep tissue (such as cerebral tissue) as opposed to shallow tissue (such as scalp), contributes to NIRS signals measured in infants. A method for separating the effects of deep- and shallow-tissue layers was applied to data of nine sleeping three-month-old infants who had been exposed to 3-s speech sounds or silence (i.e., resting state) and whose hemodynamic changes over their bilateral temporal cortices had been measured by using an NIRS system with multiple source-detector (S-D) distances. The deep-layer contribution was found to be large during resting [67% at S-D 20 mm, 78% at S-D 30 mm for oxygenated hemoglobin (oxy-Hb)] as well as during the speech condition (72% at S-D 20 mm, 82% at S-D 30 mm for oxy-Hb). A left-right connectivity analysis showed that correlation coefficients between left and right channels did not differ between original- and deep-layer signals under no-stimulus conditions and that of original- and deep-layer signals were larger than those of the shallow layer. These results suggest that NIRS signals obtained in infants with appropriate S-D distances largely reflected cerebral hemodynamic changes.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Tsukasa Funane, Fumitaka Homae, Hama Watanabe, Masashi Kiguchi, and Gentaro Taga "Greater contribution of cerebral than extracerebral hemodynamics to near-infrared spectroscopy signals for functional activation and resting-state connectivity in infants," Neurophotonics 1(2), 025003 (2 September 2014). https://doi.org/10.1117/1.NPh.1.2.025003

Published: 2 September 2014

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