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9 March 2022 Real-time interrogation of brain tumors using intraoperative FLIm
Silvia Noble Anbunesan, Alba Alfonso García, Xiangnan Zhou, Julien Bec, Roberto Frusciante, Lisanne Kraft, Brent Weyers, Matthew Bobinski, Han Sung Lee, Lee-Way Jin, Orin Bloch, Laura Marcu
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Proceedings Volume PC11949, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XX; PC1194904 (2022) https://doi.org/10.1117/12.2610424
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
The standard treatment for infiltrative gliomas is surgery to remove as much tumor tissue as possible without compromising neurological functions. Thus, real-time identification of infiltrative tumor tissue is necessary. Here a fluorescence lifetime imaging (FLIm) was used to distinguish between healthy brain and areas with different degrees of tumor cellularity as defined by histopathology. We conducted FLIm measurements and collected microbiopsies from tumor resection margins to identify the FLIm characteristics of tumor edges in cortex and white matter of low- and high-grade gliomas. Results from a 13-patient cohort indicate that FLIm identifies infiltrations of up to moderate tumor cellularity.
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Silvia Noble Anbunesan, Alba Alfonso García, Xiangnan Zhou, Julien Bec, Roberto Frusciante, Lisanne Kraft, Brent Weyers, Matthew Bobinski, Han Sung Lee, Lee-Way Jin, Orin Bloch, and Laura Marcu "Real-time interrogation of brain tumors using intraoperative FLIm", Proc. SPIE PC11949, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XX, PC1194904 (9 March 2022); https://doi.org/10.1117/12.2610424
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KEYWORDS
Tumors
Brain
Tissues
Luminescence
Neuroimaging
Laser tissue interaction
Proteins
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