Shortwave infrared preclinical tumor screening and resection via pHLIP ICG (Conference Presentation)

Ben Mc Larney; Mijin Kim; Sheryl Roberts; Magdalena Skubal; Hsiao-Ting Tsu; Anuja Ogirala; Nagavarakishore Pillarsetty; Daniel Heller; Jason S. Lewis; Jan Grimm

doi:10.1117/12.2655598

17 March 2023 Shortwave infrared preclinical tumor screening and resection via pHLIP ICG (Conference Presentation)

Ben Mc Larney, Mijin Kim, Sheryl Roberts, Magdalena Skubal, Hsiao-Ting Tsu, Anuja Ogirala, Nagavarakishore Pillarsetty, Daniel Heller, Jason S. Lewis, Jan Grimm

Author Affiliations +

Proceedings Volume PC12398, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIV; PC1239804 (2023) https://doi.org/10.1117/12.2655598
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

The advantages of shortwave infrared (SWIR, 900-1700 nm) imaging over NIR (650-900 nm) include reduced tissue optical aberrations, increased depth penetration along with improved resolution and contrast. Preclinical SWIR imaging has focused on system development and novel fluorophore development with a goal of targeted tumor resection for clinical translation. Clinical SWIR imaging has focused on indocyanine green (ICG) and the enhanced permeability and retention effect for resection with significant advantages. In this work we preclinically validate the pH low insertion peptide (pHLIP) conjugated to ICG (pHLIP ICG, currently in clinical trials) as a suitable cancer targeted fluorophore for cancer resection.

Conference Presentation

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Ben Mc Larney, Mijin Kim, Sheryl Roberts, Magdalena Skubal, Hsiao-Ting Tsu, Anuja Ogirala, Nagavarakishore Pillarsetty, Daniel Heller, Jason S. Lewis, and Jan Grimm "Shortwave infrared preclinical tumor screening and resection via pHLIP ICG (Conference Presentation)", Proc. SPIE PC12398, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIV, PC1239804 (17 March 2023); https://doi.org/10.1117/12.2655598

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KEYWORDS

Short wave infrared radiation

Tumors

Infrared imaging

Infrared radiation

Shortwaves

Near infrared

Tissues

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