pH-sensitive shortwave infrared quantum dots for In vivo pH mapping (Conference Presentation)

Manon Debayle; Xiangzhen Xu; Nicolas Lequeux; Thomas Pons

doi:10.1117/12.2545563

10 March 2020 pH-sensitive shortwave infrared quantum dots for In vivo pH mapping (Conference Presentation)

Manon Debayle, Xiangzhen Xu, Nicolas Lequeux, Thomas Pons

Proceedings Volume 11256, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII; 1125607 (2020) https://doi.org/10.1117/12.2545563
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Shortwave infrared quantum dots (QDs) are promising probes for in vivo imaging in depth. Here, we present two strategies to design pH-sensitive ratiometric QD in vivo probes. In the first one, central fluorescent QDs are coated with a copolymer ligand and conjugated to gold nanoparticle (AuNP) quenchers. As the pH decreases from physiological (7.5) to slightly acidic (5.5−6), the copolymer reversibly shrinks, which modulates the QD fluorescence signal through energy transfer. In a second design, QDs and AuNPs are encapsulated into micelles using pH-sensitive copolymer surfactants, providing stability in serum, sharp pH transitions and high contrast.

Conference Presentation

Citation Download Citation

Manon Debayle, Xiangzhen Xu, Nicolas Lequeux, and Thomas Pons "pH-sensitive shortwave infrared quantum dots for In vivo pH mapping (Conference Presentation)", Proc. SPIE 11256, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII, 1125607 (10 March 2020); https://doi.org/10.1117/12.2545563

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