Rigid endomicroscopic system for cancer diagnosis and tissue removal

Matteo Calvarese; Hyeonsoo Bae; Chenting Lai; Karl Reichwald; Tobias Meyer-Zedler; Bernhard Messerschmidt; Ayman Bali; David Pertzborn; Anna Mühlig; Orlando Guntinas-Lichius; Micheal Schmitt; Jürgen Popp

doi:10.1117/12.3009975

13 March 2024 Rigid endomicroscopic system for cancer diagnosis and tissue removal

Matteo Calvarese, Hyeonsoo Bae, Chenting Lai, Karl Reichwald, Tobias Meyer-Zedler, Bernhard Messerschmidt, Ayman Bali, David Pertzborn, Anna Mühlig, Orlando Guntinas-Lichius, Micheal Schmitt, Jürgen Popp

Author Affiliations +

Proceedings Volume PC12839, Biomedical Vibrational Spectroscopy 2024: Advances in Research and Industry; PC1283906 (2024) https://doi.org/10.1117/12.3009975
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Modern medicine faces a major challenge in preventing, diagnosing, and treating cancer, especially in its early stages. Current tools for early detection and minimally invasive treatment are insufficient. Laser-based nonlinear endoscopy combining CARS, SHG, and TPEF emerges as a promising solution for cancer diagnostics by detecting molecular changes in tissue for differentiating cancer from healthy tissue. We developed an endomicroscopic system for head and neck cancer diagnosis and femtosecond laser ablation of tissue. The system has been validated through ex-vivo measurements on patient tissue slices and machine learning methods are being developed for quantitative comparison with standard H&E histopathology. Acknowledgements: Funding from the European Community’s Horizon 2020 Programme under the grant agreement No. 860185 (PHAST), No 101016923 (CRIMSON) and from the German Federal Ministry of Education and Research (BMBF): within the project TheraOptik (FKZ 13GW0370E) and LPI (Grant Number 13N15467) is acknowledged.

Conference Presentation

Citation Download Citation

Matteo Calvarese, Hyeonsoo Bae, Chenting Lai, Karl Reichwald, Tobias Meyer-Zedler, Bernhard Messerschmidt, Ayman Bali, David Pertzborn, Anna Mühlig, Orlando Guntinas-Lichius, Micheal Schmitt, and Jürgen Popp "Rigid endomicroscopic system for cancer diagnosis and tissue removal", Proc. SPIE PC12839, Biomedical Vibrational Spectroscopy 2024: Advances in Research and Industry, PC1283906 (13 March 2024); https://doi.org/10.1117/12.3009975

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Tissues

Cancer

Imaging systems

Diagnostics

Laser ablation

Endoscopy

Femtosecond phenomena

Show All Keywords

Keywords/Phrases

Search In:

Publication Years