Ionization pattern obtained in electrospray ionization or atmospheric pressure chemical ionization interfaces for authorized antidepressants in Romania

Iulia Grecu; Mihai Ionică; Marian Vlădescu; Elena Truţă; Carmen Sultan; Oana Viscol; Luminiţa Horhotă; Simona Radu

doi:10.1117/12.2243420

14 December 2016 Ionization pattern obtained in electrospray ionization or atmospheric pressure chemical ionization interfaces for authorized antidepressants in Romania

Iulia Grecu, Mihai Ionică, Marian Vlădescu, Elena Truţă, Carmen Sultan, Oana Viscol, Luminiţa Horhotă, Simona Radu

Author Affiliations +

Proceedings Volume 10010, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies VIII; 100103H (2016) https://doi.org/10.1117/12.2243420
Event: Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies 2016, 2016, Constanta, Romania

Abstract

Antidepressants were found in 1950. In the 1990s there was a new generation of antidepressants. They act on the level of certain neurotransmitters extrasinpatic by its growth. After their mode of action antidepressants may be: SSRIs (Selective Serotonin Reuptake Inhibitors); (Serotonin-Norepinephrine Reuptake Inhibitors); SARIs (Serotonin Antagonist Reuptake Inhibitors); NRIs (Norepinephrine Reuptake Inhibitors); NDRIs (Norepinephrine-Dopamine Reuptake Inhibitors) NDRAs (Norepinephrine-Dopamine Releasing Agents); TCAs (Tricyclic Antidepressants); TeCAs (Tetracyclic Antidepressants); MAOIs (Monoamine Oxidase Inhibitors); agonist receptor 5-HT_1A (5- hydroxytryptamine); antagonist receptor 5-HT₂; SSREs (Selective Serotonin Reuptake Enhancers) and Sigma agonist receptor.

To determine the presence of antidepressants in biological products, it has been used a system HPLC-MS (High Performance Liquid Chromatography – Mass Spectrometry) Varian 12001. The system is equipped with APCI (Atmospheric Pressure Chemical Ionization) or ESI (ElectroSpray Ionization) interface. To find antidepressants in unknown samples is necessary to recognize them after mass spectrum. Because the mass spectrum it is dependent on obtaining private parameters work of HPLC-MS system, and control interfaces, the mass spectra library was filled with the mass spectra of all approved antidepressants in Romania. The paper shows the mass spectra obtained in the HPLCMS system.

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Iulia Grecu, Mihai Ionică, Marian Vlădescu, Elena Truţă, Carmen Sultan, Oana Viscol, Luminiţa Horhotă, and Simona Radu "Ionization pattern obtained in electrospray ionization or atmospheric pressure chemical ionization interfaces for authorized antidepressants in Romania", Proc. SPIE 10010, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies VIII, 100103H (14 December 2016); https://doi.org/10.1117/12.2243420

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KEYWORDS

Ionization

Interfaces

Receptors

Liquids

Atmospheric modeling

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Biological research

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