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26 April 2018 Raindrops of synaptic noise on dual excitability landscape: an approach to astrocyte network modelling
Andrey Yu. Verisokin, Dmitry E. Postnov, Darya V. Verveyko, Alexey R. Brazhe
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Proceedings Volume 10717, Saratov Fall Meeting 2017: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV; 107171S (2018) https://doi.org/10.1117/12.2315146
Event: Saratov Fall Meeting 2017, 2017, Saratov, Russian Federation
Abstract
The most abundant non-neuronal cells in the brain, astrocytes, populate all parts of the central nervous system (CNS). Astrocytic calcium activity ranging from subcellular sparkles to intercellular waves is believed to be the key to a plethora of regulatory pathways in the central nervous system from synaptic plasticity to blood flow regulation. Modeling of the calcium wave initiation and transmission and their spatiotemporal dynamics is therefore an important step stone in understanding the crucial cogs of cognition. Astrocytes are active sensors of ongoing neuronal and synaptic activity, and neurotransmitters diffusing from the synaptic cleft make a strong impact on the astrocytic activity. Here we propose a model describing the patterns of calcium wave formation at a single cell level and discuss the interplay between astrocyte shape the calcium waves dynamics driven by local stochastic surges of glutamate simulating synaptic activity.
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Andrey Yu. Verisokin, Dmitry E. Postnov, Darya V. Verveyko, and Alexey R. Brazhe "Raindrops of synaptic noise on dual excitability landscape: an approach to astrocyte network modelling", Proc. SPIE 10717, Saratov Fall Meeting 2017: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV, 107171S (26 April 2018); https://doi.org/10.1117/12.2315146
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KEYWORDS
Calcium
Diffusion
Modeling
Neurotransmitters
Stochastic processes
Nervous system
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