Development of anti-cadherin-17 antibody -IR700 conjugate for photodynamic therapy against gastrointestinal cancers

Yick-Liang Lum; Dennis K. P. Ng; John M. Luk; Wing-Ping Fong

doi:10.1117/12.2525313

7 August 2019 Development of anti-cadherin-17 antibody -IR700 conjugate for photodynamic therapy against gastrointestinal cancers

Yick-Liang Lum, Dennis K. P. Ng, John M. Luk, Wing-Ping Fong

Author Affiliations +

Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 110702V (2019) https://doi.org/10.1117/12.2525313
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States

Abstract

The lack of tumor specificity by photosensitizers often hampers the clinical application of photodynamic therapy (PDT). Delivery of photosensitizer to tumor based entirely on the enhanced permeability and retention effect could lead to nonspecific uptake of photosensitizer by normal tissue, causing adverse effect in patients. Accumulating evidence showed that the combination of antibody immunotherapy and PDT can complement each other to produce effective cancer-targeted photoimmunotherapy. IRDye 700DX (IR700) is a water-soluble phthalocyanine-based photosensitizer that can produce reactive oxygen species (ROS) efficiently upon light irradiation. Cadherin-17 (CDH17) is a cell surface antigen commonly overexpressed in gastrointestinal cancers. By conjugating IR700 to anti-CDH17 humanized monoclonal antibody (ARB102), the conjugate could target CDH17 positive cancer cells and achieve selective accumulation to induce potent cytotoxicity upon light irradiation.

Conference Presentation

Citation Download Citation

Yick-Liang Lum, Dennis K. P. Ng, John M. Luk, and Wing-Ping Fong "Development of anti-cadherin-17 antibody -IR700 conjugate for photodynamic therapy against gastrointestinal cancers", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110702V (7 August 2019); https://doi.org/10.1117/12.2525313

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