Characterization of interfacial failure in cemented total joint replacements via self-sensing bone cement, electrical impedance tomography, and machine learning

H. Ghaednia; C. E. Owens; L. E. Keiderling; A. J. Hart; K. M. Varadarajan; J. Schwab; T. N. Tallman

doi:10.1117/12.2581950

22 March 2021 Characterization of interfacial failure in cemented total joint replacements via self-sensing bone cement, electrical impedance tomography, and machine learning

H. Ghaednia, C. E. Owens, L. E. Keiderling, A. J. Hart, K. M. Varadarajan, J. Schwab, T. N. Tallman

Author Affiliations +

Proceedings Volume 11593, Health Monitoring of Structural and Biological Systems XV; 1159310 (2021) https://doi.org/10.1117/12.2581950
Event: SPIE Smart Structures + Nondestructive Evaluation, 2021, Online Only

Abstract

At an estimated cost of $8 billion annually in the United States, revision total joint replacement surgeries represent a substantial financial burden to the health care system. Fixation failures such as implant loosening and mechanical instability at the cement-to-bone interface are the main causes of long-term implant failure. Early and accurate diagnosis of cement-bone interface failure is critical to develop therapeutic strategies and reduce the risk of delayed revision surgery. Unfortunately, prevailing imaging modalities such as plain radiographs struggle to detect the precursors of implant failure and are often interpreted incorrectly. Our team has recently shown that modification of poly(methyl methacrylate) (PMMA) bone cement with low concentrations of conductive fillers makes it piezoresistive and therefore self-sensing. By electrical impedance tomography (EIT) it is possible to monitor load transfer across the PMMA using real-time electrical measurements, which are physiologically benign and would ultimately be cost-effective in a clinical setting. Herein, we demonstrate the use of machine learning with EIT in order to precisely characterize model failure events. In phantom tests, we introduce three defect types: loosening, vertical cracks, and horizontal cracks. We show that implant defect type can be classified with greater than 95% accuracy by combining principal component analysis (PCA) coupled with the k-nearest neighbor (KNN) algorithm and a two layer feed-forward neural network with three hidden neurons . These preliminary results show that the combination of smart materials, EIT, and machine learning may be a powerful tool for predicting and diagnosing failure in joint replacements.

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H. Ghaednia, C. E. Owens, L. E. Keiderling, A. J. Hart, K. M. Varadarajan, J. Schwab, and T. N. Tallman "Characterization of interfacial failure in cemented total joint replacements via self-sensing bone cement, electrical impedance tomography, and machine learning", Proc. SPIE 11593, Health Monitoring of Structural and Biological Systems XV, 1159310 (22 March 2021); https://doi.org/10.1117/12.2581950

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