Towards in vivo imaging of ganglion cell layer somas using widely-available clinical OCT devices

Furu Zhang; Catherine A. Cukras; Daniel X. Hammer; Zhuolin Liu

doi:10.1117/12.2582785

5 March 2021 Towards in vivo imaging of ganglion cell layer somas using widely-available clinical OCT devices

Furu Zhang, Catherine A. Cukras, Daniel X. Hammer, Zhuolin Liu

Proceedings Volume 11623, Ophthalmic Technologies XXXI; 116230Y (2021) https://doi.org/10.1117/12.2582785
Event: SPIE BiOS, 2021, Online Only

Abstract

The development and application of adaptive optics (AO) in retinal imaging have enabled visualization of a plethora of retinal cells and structures. However, major hurdles exist for translating these achievements to the widely-available clinical devices for broad clinical applications. Here, by configuring a research grade AO – optical coherence tomography (AO-OCT) system to simulate a clinical OCT device, we provide evidence that clinical OCT systems have the potential to resolve individual ganglion cell layer somas and determine that a lateral sampling of ~1.5 µm/pixel is required to accurately quantify soma density and size.

Conference Presentation

Citation Download Citation

Furu Zhang, Catherine A. Cukras, Daniel X. Hammer, and Zhuolin Liu "Towards in vivo imaging of ganglion cell layer somas using widely-available clinical OCT devices", Proc. SPIE 11623, Ophthalmic Technologies XXXI, 116230Y (5 March 2021); https://doi.org/10.1117/12.2582785

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