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5 March 2021 Non-invasive, label-free, two-photon detection of epithelial metabolic precursors to repigmentation in vitiligo micrografts
Christopher Polleys, Griffin Lentsch, Bruce Tromberg, Anand Ganesan M.D., Francisca Rius-Diaz, Mihaela Balu, Irene Georgakoudi
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Proceedings Volume 11655, Label-free Biomedical Imaging and Sensing (LBIS) 2021; 116550F (2021) https://doi.org/10.1117/12.2578676
Event: SPIE BiOS, 2021, Online Only
Abstract
Vitiligo is a disorder characterized by the loss of skin pigment due to the autoimmune destruction of epidermal melanocytes. Treatments that aim to repigment vitiligo regions are long, incomplete, and suffer from a highly variable success rate. This study aims to use non-invasive, depth-resolved, label-free, two-photon detection of reduced nicotinamide adenine dinucleotide (NADH) to quantitatively evaluate mitochondrial dynamics in vitiligo micrografting patients during the repigmentation process. This study indicates differences in the depth-dependent mitochondrial profiles between healthy and vitiligo tissues. This study also indicates that vitiligo regions responsive to treatment exhibit depth-dependent shifts in mitochondrial dynamics prior to repigmentation.
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Christopher Polleys, Griffin Lentsch, Bruce Tromberg, Anand Ganesan M.D., Francisca Rius-Diaz, Mihaela Balu, and Irene Georgakoudi "Non-invasive, label-free, two-photon detection of epithelial metabolic precursors to repigmentation in vitiligo micrografts", Proc. SPIE 11655, Label-free Biomedical Imaging and Sensing (LBIS) 2021, 116550F (5 March 2021); https://doi.org/10.1117/12.2578676
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KEYWORDS
Skin
Luminescence
Multiphoton microscopy
Multiphoton processes
Phototherapy
Tissues
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