Presentation
1 August 2021 3D Cell-Rotation using Multi-Core Fiber-based Lab-on-a-Chip and Wavefront Shaping
Author Affiliations +
Abstract
Optical dual-beam trapping is a vital tool in biology. However, a precise rotation of large cells in 3D about arbitrary axes has not been reported yet with dual-beam traps. We introduce a novel multi-core fiber-based dual-beam optical trap using wavefront shaping. Real-time controlled rotation of HL60 cells for cancer studies is demonstrated. For the first time, the orientation of the cell can be precisely controlled about all 3D axes in a dual beam trap. Multi-core fibers provide much higher flexibility beyond the bulky optics, enabling lab-on-a-chip applications and can be easily integrated for applications like non-invasive refractive index tomography and cell-elasticity measurements.
Conference Presentation
© (2021) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Jürgen W. Czarske "3D Cell-Rotation using Multi-Core Fiber-based Lab-on-a-Chip and Wavefront Shaping", Proc. SPIE 11798, Optical Trapping and Optical Micromanipulation XVIII, 117981F (1 August 2021); https://doi.org/10.1117/12.2596236
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KEYWORDS
Lab on a chip

Wavefronts

3D metrology

Holography

Optical manipulation

Optical tweezers

Refractive index

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