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17 March 2023 Dual-excitation multispectral autofluorescence lifetime endoscopy for clinical label-free metabolic imaging of oral lesions
Rodrigo Cuenca Martinez, Michael J. Serafino, Gabriel P. Tortorelli, Ronald C. Faram, Kathleen E. Higgins, Sharukh S. Khajotia, Yi-Shing L. Cheng, Jacqueline M. Plemons, Victoria Woo, Carlos Busso Recabarren, Kayla R. Caughlin, Javier A. Jo
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Proceedings Volume 12354, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2023; 1235409 (2023) https://doi.org/10.1117/12.2647972
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
We report a new approach for label-free metabolic imaging of oral lesions using a novel fluorescence lifetime imaging endoscopy (FLIMEnd) system. The FLIMEnd system is capable of simultaneous dual-wavelength excitation and fluorescence detection at four emission spectral bands. Preliminary results indicate that established metabolic autofluorescence biomarkers of oral pre-malignancy and malignancy can be clinically imaged with this novel FLIMEnd technology. Future work will focus on identifying both established and novel autofluorescence biomarkers of oral pre-cancer and cancer that can be used to develop machine-learning driven FLIMEnd systems for early detection of oral cancer.
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Rodrigo Cuenca Martinez, Michael J. Serafino, Gabriel P. Tortorelli, Ronald C. Faram, Kathleen E. Higgins, Sharukh S. Khajotia, Yi-Shing L. Cheng, Jacqueline M. Plemons, Victoria Woo, Carlos Busso Recabarren, Kayla R. Caughlin, and Javier A. Jo "Dual-excitation multispectral autofluorescence lifetime endoscopy for clinical label-free metabolic imaging of oral lesions", Proc. SPIE 12354, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2023, 1235409 (17 March 2023); https://doi.org/10.1117/12.2647972
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KEYWORDS
Endoscopy
Cancer
Imaging systems
Fluorescence lifetime imaging
Fluorescence spectroscopy
Image resolution
Luminescence
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