Assessment of corneal stiffness ex-vivo at various IOPs measured by heartbeat OCE

Andres Bryan; Achuth Nair; Manmohan Singh; Salavat Aglyamov; Kirill V. Larin

doi:10.1117/12.2651304

15 March 2023 Assessment of corneal stiffness ex-vivo at various IOPs measured by heartbeat OCE

Andres Bryan, Achuth Nair, Manmohan Singh, Salavat Aglyamov, Kirill V. Larin

Proceedings Volume 12381, Optical Elastography and Tissue Biomechanics X; 123810D (2023) https://doi.org/10.1117/12.2651304
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Measuring corneal biomechanical properties provides important diagnostic information regarding tissue health and for evaluating the outcomes of therapies. Heartbeat OCE (Hb-OCE), a truly passive elastography technique, utilizes the pulsatile nature of the intraocular pressure (IOP) to quantify corneal stiffness completely noninvasively and with no external excitation. In this work, we utilized whole rabbit eye globes to quantify the displacement and strain in the cornea by fluctuating the IOP ex-vivo. We also approximated the non-linearity of the stiffness of the cornea by performing HbOCE measurements at various baseline IOPs. The results show an expected increase in corneal stiffness as the baseline IOP increased, demonstrating the effectiveness of Hb-OCE as a tool for measuring corneal biomechanical properties completely noninvasively and with no external excitation.

Conference Presentation

Citation Download Citation

Andres Bryan, Achuth Nair, Manmohan Singh, Salavat Aglyamov, and Kirill V. Larin "Assessment of corneal stiffness ex-vivo at various IOPs measured by heartbeat OCE", Proc. SPIE 12381, Optical Elastography and Tissue Biomechanics X, 123810D (15 March 2023); https://doi.org/10.1117/12.2651304

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