3D heartbeat optical coherence elastography to map the elasticity of the cornea

Sharon Shajan; Achuth Nair; Manmohan Singh; Salavat Aglyamov; Kirill V. Larin

doi:10.1117/12.2692996

12 March 2024 3D heartbeat optical coherence elastography to map the elasticity of the cornea

Sharon Shajan, Achuth Nair, Manmohan Singh, Salavat Aglyamov, Kirill V. Larin

Proceedings Volume 12844, Optical Elastography and Tissue Biomechanics XI; 1284408 (2024) https://doi.org/10.1117/12.2692996
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Assessing corneal biomechanical properties may be important for the diagnosis of ocular diseases as the mechanical properties of the cornea change during disease development. Elastography is a technique to image the mechanical properties of tissues by applying a mechanical load to the tissue and measuring the resultant displacement using available imaging techniques like magnetic resonance or ultrasound imaging. The measured displacement is then translated to mechanical properties. Heartbeat optical coherence elastography (Hb-OCE) is a completely passive elastography technique, which uses physiological perturbations naturally present in the body in lieu of active tissue stimulation sources. In this work, we demonstrate the first use of 3D Hb-OCE to measure the biomechanical properties of the cornea in 3D in an ex vivo porcine eye. Measurements were taken on whole porcine eye globes using a Fourier Domain Mode Locked swept source laser-based OCT system with a volume rate of 4.2 Hz. The strain in the cornea was measured between successive B-scans during a simulated ocular pulse, and each scan was stacked together to obtain 3D volumetric strain due to the simulated heartbeat. This technique may potentially enable full volumetric analysis of corneal mechanical properties completely passively. Future work will focus on 3D evaluation of customized corneal crosslinking and in vivo translation of the 3D Hb-OCE technique.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Sharon Shajan, Achuth Nair, Manmohan Singh, Salavat Aglyamov, and Kirill V. Larin "3D heartbeat optical coherence elastography to map the elasticity of the cornea", Proc. SPIE 12844, Optical Elastography and Tissue Biomechanics XI, 1284408 (12 March 2024); https://doi.org/10.1117/12.2692996

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