Significant reduction in the duration of transient voltage responses of a plasmonic nanopore sensor by use of a Chebyshev filter

Homayoun Asadzadeh; Scott Turpin; Scott Renkes; Min Jun Kim; George Alexandrakis

doi:10.1117/12.2650798

16 March 2023 Significant reduction in the duration of transient voltage responses of a plasmonic nanopore sensor by use of a Chebyshev filter

Homayoun Asadzadeh, Scott Turpin, Scott Renkes, Min Jun Kim, George Alexandrakis

Author Affiliations +

Proceedings Volume 12396, Plasmonics in Biology and Medicine XX; 1239606 (2023) https://doi.org/10.1117/12.2650798
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We present the effects of a Chebyshev filter circuit on the transient electrical current responses of a plasmonic nanopore sensor during abrupt voltage reversals. Those reversals are similar to ones used for single molecule capture-recapture with electrical nanopores. Our plasmonic nanopore sensor allows simultaneous recording of optical and electrical data during optical trapping of nanoparticles and their subsequent translocation through the nanopore located at the sensor’s center. The technical challenge this work aims to resolve is that the sensor’s transient response to abrupt voltage reversals is strong (near-saturation current spikes) and is also slow (return to baseline in the ms range). During this refractory period an analyte’s translocation may be obfuscated by the sensor’s transient response. Here we test the use of a Chebyshev filter as a possible means of significantly reducing the sensor’s transient response to voltage reversals so that analyte translocations are not masked by those transient responses. At the same time, we also test that electrical signatures detected during trapping of a test analyte (20 nm SiO2 nanoparticles) are not unintentionally also removed by the same filter. This work is as a first step towards developing a methodology for enabling rapid analyte recapture by our plasmonic nanopore sensor.

Conference Presentation

Citation Download Citation

Homayoun Asadzadeh, Scott Turpin, Scott Renkes, Min Jun Kim, and George Alexandrakis "Significant reduction in the duration of transient voltage responses of a plasmonic nanopore sensor by use of a Chebyshev filter", Proc. SPIE 12396, Plasmonics in Biology and Medicine XX, 1239606 (16 March 2023); https://doi.org/10.1117/12.2650798

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