Metamaterial enhanced novel plasmonic biosensor for specific detection of SARS-CoV-2 spike protein

Yingxin Zhou; Yongping Li; Qian Liu; Yufeng Yuan; Xiao Peng; Jun Song; Junle Qu

doi:10.1117/12.2651677

23 January 2023 Metamaterial enhanced novel plasmonic biosensor for specific detection of SARS-CoV-2 spike protein

Yingxin Zhou, Yongping Li, Qian Liu, Yufeng Yuan, Xiao Peng, Jun Song, Junle Qu

Proceedings Volume 12556, AOPC 2022: Optoelectronics and Nanophotonics; 125561O (2023) https://doi.org/10.1117/12.2651677
Event: Applied Optics and Photonics China 2022 (AOPC2022), 2022, Beijing, China

Abstract

In this study, we theoretically propose a surface plasmon resonance (SPR) biosensor composed of a plasmonic gold film, double negative (DNG) metamaterial, graphene-MoS2−COOH Van der Waals heterostructures and gold nanoparticles (Au NPs). We use a novel scheme of Goos-Hänchen (GH) shift to study the biosensing performances of our proposed plasmonic biosensor. The calculation results show that, both an extreme low reflectivity of 8.52×10^-10 and significantly enhanced GH sensitivity of 2.1530×10⁷ μm/RIU can be obtained, corresponding to the optimal configuration: 32 nm Au film/120 nm metamaterial/4-layer graphene/4-layer MoS₂−COOH. In addition, there is a theoretically excellent linear response between the concentration of target analytes (SARS-CoV-2 and S protein) and the change in differential GH shift. Our proposed biosensor promises to be a useful tool for performing the novel coronavirus detection.

Citation Download Citation

Yingxin Zhou, Yongping Li, Qian Liu, Yufeng Yuan, Xiao Peng, Jun Song, and Junle Qu "Metamaterial enhanced novel plasmonic biosensor for specific detection of SARS-CoV-2 spike protein", Proc. SPIE 12556, AOPC 2022: Optoelectronics and Nanophotonics, 125561O (23 January 2023); https://doi.org/10.1117/12.2651677

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available