Observing cross-species cross-cancer chemosensitivity signatures with dynamic-contrast OCT

Dawith Lim; Zhen Hua; Zhe Li; Ali Ajrouch; Ahmad Karkash; Shadia Jalal; Michael Childress; John Turek; David Nolte

doi:10.1117/12.3002602

12 March 2024 Observing cross-species cross-cancer chemosensitivity signatures with dynamic-contrast OCT

Dawith Lim, Zhen Hua, Zhe Li, Ali Ajrouch, Ahmad Karkash, Shadia Jalal, Michael Childress, John Turek, David Nolte

Proceedings Volume 12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; 128300V (2024) https://doi.org/10.1117/12.3002602
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Despite improvements in the ability to treat cancer, first-line chemotherapy in standard-of-care treatments still fail to elicit a response from about half of cancer patients. This limitation signals a pressing need for practical methods to select personalized cancer therapies. Biodynamic imaging (BDI; a form of dynamic-contrast OCT with low-coherence digital holography) on living cancer biopsies from patients shows potential as a method to guide personalized selection of cancer therapy. However, building a library of signatures for different types of cancer has been a practical obstacle. Here, a comparative preclinical/clinical trial with two-species (human and canine) and two-cancers (esophageal carcinoma and B-cell lymphoma) demonstrates the general applicability of BDI as a method of chemoresistance prediction and as a viable tool for personalized medicine. This study identifies a set of drug response phenotypes that span species and cancer type, suggesting the existence of universal characteristics, which would reduce the burden of library construction needed for the method to be useful for doctors and their patients.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Dawith Lim, Zhen Hua, Zhe Li, Ali Ajrouch, Ahmad Karkash, Shadia Jalal, Michael Childress, John Turek, and David Nolte "Observing cross-species cross-cancer chemosensitivity signatures with dynamic-contrast OCT", Proc. SPIE 12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, 128300V (12 March 2024); https://doi.org/10.1117/12.3002602

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available