Prof. David D. Nolte
Professor of Physics and Astronomy at Purdue Univ
SPIE Involvement:
Author | Instructor
Publications (73)

Proceedings Article | 13 March 2024 Presentation + Paper
Dawith Lim, Zhen Hua, Zhe Li, Ali Ajrouch, Ahmad Karkash, Shadia Jalal, Michael Childress, John Turek, David Nolte
Proceedings Volume 12830, 128300V (2024)
KEYWORDS: Cancer, Optical coherence tomography, Oncology, Doppler effect, Digital holography

Proceedings Article | 8 March 2023 Presentation + Paper
Zhen Hua, Shadia Jalal, John Turek, David Nolte
Proceedings Volume 12367, 123670L (2023)
KEYWORDS: Biopsy, Cancer, Neural networks, Optical coherence tomography, Deep learning, Chemotherapy, Biological samples, Tissues, Tumors, Spectral response

Proceedings Article | 2 March 2022 Paper
Zhen Hua, John Turek, David Nolte
Proceedings Volume 11959, 1195906 (2022)
KEYWORDS: Biopsy, Tissue optics, Seaborgium, Spectroscopy, Tumors, Holograms, Dynamic light scattering, Digital holography, Beam splitters, Light scattering

Proceedings Article | 9 December 2021 Paper
David Nolte, Ran An, John Turek
Proceedings Volume 11924, 119240I (2021)
KEYWORDS: Cancer, Doppler effect, Clinical trials, Tumors, Biopsy, Tissues, Tissue optics, Imaging systems, Digital holography, Spectroscopy

SPIE Journal Paper | 29 March 2021 Open Access
Kwan Jeong, Maria Josef Lopera, John Turek, David Nolte
JBO, Vol. 26, Issue 03, 030501, (March 2021)
KEYWORDS: Digital holography, Interferometers, Holography, Spectroscopy, Doppler tomography, Tissues, Interferometry, Holographic interferometry, Diffraction gratings, 3D image reconstruction

Showing 5 of 73 publications
Conference Committee Involvement (1)
Ultrafast Phenomena in Semiconductors VII
29 January 2003 | San Jose, CA, United States
Course Instructor
SC1054: Bio-Interferometry: Fundamentals and Applications to Biosensors, Drug Discovery, Microscopy and Biomedical Imaging
This course explains the basic principles of optical interferometry applied to biological problems and systems. Interference is at the core of many types of optical detection and is a powerful probe of cellular and tissue structure such as for interference microscopy and optical coherence tomography. Interference is also the root cause of speckle and other imaging artifacts that limit range and resolution. Furthermore, the inherent sensitivity of interferometry enables ultrasensitive detection of molecules in biological samples for medical diagnostics using biosensors. In this course, emphasis is placed on the physics of light scattering, with a focus on coherence detection techniques that allow information to be selectively detected out of incoherent and heterogeneous backgrounds. <p> </p>Bio-Interferometry is divided into four parts. The first part covers fundamental principles of partial coherence and interferometry. The next three parts move up successive size scales: biosensors and molecular interferometry (nano-scale), cellular interferometry and microscopy (micron-scale), and ending with tissue interferometry and holography (millimeter scale). The course clearly presents the physics, with easy derivations of the appropriate equations, while emphasizing "rules of thumb" that can be applied by experimental researchers to give semi-quantitative predictions.
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