Comparison of optical coherence elastography and ultrasound elastography for detecting systemic sclerosis: preliminary results from a prospective clinical trial

Harshdeep Singh Chawla; Ruhani Desai; Pavel Nikitin; Meng Zhang; Samuel Theodore; Manmohan Singh; Salavat R. Aglyamov; Kirill V. Larin; Shervin Assassi

doi:10.1117/12.3001633

12 March 2024 Comparison of optical coherence elastography and ultrasound elastography for detecting systemic sclerosis: preliminary results from a prospective clinical trial

Harshdeep Singh Chawla, Ruhani Desai, Pavel Nikitin, Meng Zhang, Samuel Theodore, Manmohan Singh, Salavat R. Aglyamov, Kirill V. Larin, Shervin Assassi

Author Affiliations +

Proceedings Volume 12844, Optical Elastography and Tissue Biomechanics XI; 128440A (2024) https://doi.org/10.1117/12.3001633
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Systemic sclerosis (SSc) is a rare, chronic autoimmune disease characterized by fibrosis and vascular abnormalities in multiple organs, including skin, lungs, and gastrointestinal tract. Early and accurate diagnosis of SSc is essential for timely intervention and improved patient outcomes. More than 90% of patients with SSc have fibrosis in the skin that manifests as mechanical changes in the skin. The modified Rodnan Skin Score (mRSS) is the gold standard for assessing skin involvement in SSc but has high inter-observer variability. The other widely used method is ultrasound imaging. Ultrasound elastography is emerging as a useful technique for assessing SSc, but its accuracy is still under investigation. Even though the results from these studies provide a quantitative assessment of SSc, ultrasound elastography has many limits, such as the lack of high-resolution performance to detect SSc-affected skin structural and elastic characteristics simultaneously. Optical coherence elastography (OCE) is an established technique to assess the mechanical properties of tissues noninvasively and quantitatively with high resolution. We measured the mechanical properties of skin in 45 patients (36 SSc and 9 matched controls) using a home-built swept source OCE setup that uses air-coupled acoustic radiation force for tissue excitation. The measurements were performed at three locations on each arm: the proximal phalanx of the third finger, the second intermetacarpal space, and the dorsal forearm midline. The OCE results were compared to mRSS and clinical ultrasound elastography, which a trained physician performed. Our results show that OCE outperformed ultrasound elastography with a higher correlation with mRSS.

Conference Presentation

Citation Download Citation

Harshdeep Singh Chawla, Ruhani Desai, Pavel Nikitin, Meng Zhang, Samuel Theodore, Manmohan Singh, Salavat R. Aglyamov, Kirill V. Larin, and Shervin Assassi "Comparison of optical coherence elastography and ultrasound elastography for detecting systemic sclerosis: preliminary results from a prospective clinical trial", Proc. SPIE 12844, Optical Elastography and Tissue Biomechanics XI, 128440A (12 March 2024); https://doi.org/10.1117/12.3001633

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available