Real-time in-vivo volumetric quantitative phase imaging with a compact handheld probe

Zhe Guang; Paloma Casteleiro Costa; Zhenmin Li; Joshua Lerner; Francisco E. Robles

doi:10.1117/12.3000269

12 March 2024 Real-time in-vivo volumetric quantitative phase imaging with a compact handheld probe

Zhe Guang, Paloma Casteleiro Costa, Zhenmin Li, Joshua Lerner, Francisco E. Robles

Proceedings Volume 12852, Quantitative Phase Imaging X; 1285206 (2024) https://doi.org/10.1117/12.3000269
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Quantitative phase imaging (QPI) offers label-free access to refractive index information of biological samples, which can achieve nanometer-level optical-path-length sensitivity with cellular/sub-cellular biophysical and histological details. Recently we introduced quantitative oblique back-illumination microscopy (qOBM) which works in epi-mode and uses multiply scattered photons within thick samples to yield quantitative phase in thick scattering tissues, thus overcoming QPI’s long-standing limitation to thin transparent samples. qOBM provides real-time quantitative phase in 3D, and can be configured in a compact form factor. Here we describe a handheld qOBM probe, suitable for in-vivo diagnostic applications such as brain tumor assessment, dermatology, and more.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Zhe Guang, Paloma Casteleiro Costa, Zhenmin Li, Joshua Lerner, and Francisco E. Robles "Real-time in-vivo volumetric quantitative phase imaging with a compact handheld probe", Proc. SPIE 12852, Quantitative Phase Imaging X, 1285206 (12 March 2024); https://doi.org/10.1117/12.3000269

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