Photodynamic effect of different aluminum and zinc phthalocyanines on isolated nerve cell

Anatoly B. Uzdensky; Anna A. Zhavoronkova; Olga Yu. Dergacheva; Valentina M. Derkacheva

doi:10.1117/12.375260

30 December 1999 Photodynamic effect of different aluminum and zinc phthalocyanines on isolated nerve cell

Anatoly B. Uzdensky, Anna A. Zhavoronkova, Olga Yu. Dergacheva, Valentina M. Derkacheva

Proceedings Volume 4059, Laser Use in Oncology II; (1999) https://doi.org/10.1117/12.375260
Event: Selected Papers on Laser Use in Oncology II, 1999, none, Armenia

Abstract

The photodynamic effects of sulphonated zinc (ZnPcS₂, ZnPcS₃ and ZnPcS₄) and aluminum (AlPcS₃) phthalocyanines as well as phosphonated aluminum phthalocyanine on the firing of isolated crayfish mechanoreceptor neurons were studied. After 30 min photosensitization neurons were irradiated with He-Ne laser (632.8 nm, 0.3 W/cm²) and changes in neuron firing frequency were recorded. Neuron firing was found to be very sensitive to photodynamic impact and served as a sensitive indicator of cell photodamage. The dynamics of the neuron responses to photodynamic effects included stages of firing activation and/or inhibition prior to irreversible firing abolition and depended on the photosensitizer type and concentration. The comparison of the dependencies of neuron lifetime on photosensitizer concentrations showed that the most effective photosensitizer was ZnPcS₂. High photodynamic efficiencies of phthalocyanines was related with the weak dependence of photodynamic effect on sensitizer concentration indicating to the initiation about 3 secondary chain processes such as free radical membrane damage caused by photon absorption by one photosensitizer molecule.

Citation Download Citation

Anatoly B. Uzdensky, Anna A. Zhavoronkova, Olga Yu. Dergacheva, and Valentina M. Derkacheva "Photodynamic effect of different aluminum and zinc phthalocyanines on isolated nerve cell", Proc. SPIE 4059, Laser Use in Oncology II, (30 December 1999); https://doi.org/10.1117/12.375260

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