Measuring liquid volumes in subnanoliter wells

Ian T. Young; Kari H. Hjelt; L. Richard van den Doel; Michael J. Vellekoop; Lucas J. van Vliet

doi:10.1117/12.427959

21 May 2001 Measuring liquid volumes in subnanoliter wells

Ian T. Young, Kari H. Hjelt, L. Richard van den Doel, Michael J. Vellekoop, Lucas J. van Vliet

Proceedings Volume 4265, Biomedical Instrumentation Based on Micro- and Nanotechnology; (2001) https://doi.org/10.1117/12.427959
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

We are developing a method for high-throughput screening using arrays of `nanowells' built into a silicon substrate. These wells can serve as bioreactors for studying a variety of biochemical reactions such as the enzymatic activity that occurs in yeast metabolism. For a variety of studies it is important to know the volume of liquid that has been deposited in a given well and/or to monitor the evaporation of the liquid. Using silicon as our substrate means that we can take advantage of the ability to build microelectronics into the wells in order to develop `smart' wells.

Citation Download Citation

Ian T. Young, Kari H. Hjelt, L. Richard van den Doel, Michael J. Vellekoop, and Lucas J. van Vliet "Measuring liquid volumes in subnanoliter wells", Proc. SPIE 4265, Biomedical Instrumentation Based on Micro- and Nanotechnology, (21 May 2001); https://doi.org/10.1117/12.427959

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